Oxidative Medicine and Cellular Longevity. Efficacy of lycopene in the treatment of gingivitis: a randomised, placebo-controlled clinical trial. Lycopene benefits the skin by helping it resist ultraviolet rays. New research on lycopene, a unique carotenoid, has shown it has an ability to defend against some of the factors of skin aging. 2007 Jul;18(7):449-56. It was found that topical application of lycopene suppressed the typical UVB-induced activity of an enzyme called ornithine decarboxylase, an important initiating and rate-controlling factor involved in stabilizing DNA structure in the nucleus of the skin cells as well as maintaining the DNA double strand-break repair pathway.9 What this means is that lycopene was able to offer significant protection to the cellular DNA and thus negated the need for the body to activate its internal DNA repair pathways. 6. Nutrition Research. Let food be your medicine: nutraceutical properties of lycopene. Plasma membrane channels formed by connexins: their regulation and functions. 2007 Mar;55(3):207-16. Lycopene health benefits include treating neurological disorder, preventing stroke, supporting immune system, preventing macular degeneration, alleviating osteoporosis, fighting diabetes, treating prostate cancer, controlling cholesterol level, treating infertility, promoting hair growth, treating scalp diseases, and slowing down aging process. American Journal of Epidemiology. Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC. Molecular Nutrition and Food Research. Epub 2007 Jan 25. The most probable mechanism against skin photodamage is attributed to the antioxidant property of lycopene and its singlet oxygen-quenching ability3. The lycopene in supplements is about as easy for the body to use as lycopene found in food. (1) It helps the skin look younger by boosting collagen production and in turn reducing the appearance of fine lines, wrinkles and age spots. Topical use of vitamin K may also treat rosacea, a chronic, inflammatory skin condition characterized by redness and pimples on the face. The Journal of Nutrition. They combat inflammation, thereby preventing serious ailments like cancer and heart disease. 2003 Oct;41(10):1399-407. There are two major types of ultra-violet (UV) radiation that reach us from the sun: UV-A penetrates deep into the skin. Rao AV, Rao LG. Oxidative stress breaks down collagen, hinders skin’s natural repair process and triggers inflammation—and you see these as fine lines, wrinkles, loose skin, acne breakouts and a blotchy skin tone. "Lycopene is present in fruits and vegetables to help prevent damage caused by light," says Amy Hart, product development manager for Yes To. 2017;61(5). Theoretically, lycopene's ability to regulate cell-to-cell junctions might provide an additional benefit of improving skin texture. 2010;164(1):154–162. What are the benefits of using skincare and cosmetics that contain topical lycopene, plant extracts, vitamins, and minerals? Namitha KK, Negi PS. Lycopene Benefits & Skin Health. Chen P, Zhang W, Wang X, Zhao K, Negi DS, Zhuo L, Qi M, Wang X, Zhang X. Lycopene and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis. Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Lycopene may also strengthen your skin by inhibiting the activity of enzymes involved in the destruction of collagen.14 This reaction breaks down the peptide bonds in the collagen fibers of your skin, resulting in gradual loss of integrity and the appearance of sags and wrinkles. Medicine (Baltimore). 7. 1995;125(7):1854–1859. Skin Lycopene Is Destroyed Preferentially over β-Carotene during Ultraviolet Irradiation in Humans. 2008; 60(3):342-53. Our products are infused with micro-dispersed aquose Lycopene, which is the #1 antioxidant recommended by Doctors. Free Radical Research. Written By Gary Goldfaden, MD And Robert Goldfaden. 2008;42(1):94-102. Prediagnostic levels of serum micronutrients in relation to risk of gastric cancer in Shanghai, China. The researchers found that the serum lycopene levels were generally low, mean value 223.5 nM and 290.6 nM for the young and middle-aged group, respectively. The protective role of skin lycopene is not only limited to ultraviolet radiation-induced skin erythema, premature skin aging (skin inelasticity, coarse wrinkles, skin pigmentation) but may also extend in the prevention and management of skin cancer3,4. Topical Lycopene Improves Skin Cellular Function. Furthermore, lycopene may offer beneficial effects on male infertility, Down’s syndrome and Alzheimer’s disease19,20. Lycopene also protects your skin, thanks to its photoprotective properties. Critical Reviews in Food Science and Nutrition. Alda LM, Gogoasa I, Bordean DM, et al. The antioxidant properties help balance free radical activity in the body and in doing so, may offer protection against certain diseases, keep bones strong and healthy, and help eyesight by helping delay or prevent cataracts, macular degeneration, and other age-rela… Rizwan M, Rodriguez-Blanco I, Harbottle A, Birch-Machin MA, Watson REB, Rhodes LE. The 5 Main Benefits of Antioxidants for Your Skin Antioxidants help correct signs of age. British Journal of Dermatology. DMAE helps to tighten skin and reduce sagging, improve firmness and elasticity, smooth lines and wrinkles, and brighten the skin. Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept. Ratings based on results of the 2020 ConsumerLab.com survey of supplement users. 2010 Sep;50(8):728-60. Khachik F, Carvalho L, Bernstein PS, Muir GJ, Zhao DY, Katz NB. 2016;2016:8214631. Lycopene belongs to a general group of more than 600 fat-soluble plant compounds known as carotenoids. J Nutr Biochem. 31-33 Polyphenols are a dynamic group of approximately 8,000 organic compounds that are widely distributed in the plant kingdom. Lycopene can benefit any skin type, but works especially well for sensitive and aging skin. This salt may also be used for purposes not listed in this medication guide. Lycopene may help increase your skin’s defense against sunburns and damage caused by UV rays. Shop our collection of natural skin care products sourced from all over the world. Lycopene also reported to have protective roles in gingivitis and bleeding, osteoporosis, mental disorders, and asthma15-18. Ribaya-Mercado JD, Garmyn M, Gilchrest BA, Russell RM. Some people claim the enzymes in tomatoes can offer exfoliation benefits when applied to the skin. As such, we have a more recent article on this topic: Retinol Blend Reverses Skin Aging. Moreover, because lycopene is especially effective in tissues with high fat content, the lipid-rich environment of the skin provides a very receptive target for its potent anti-aging benefits.7, Lycopene's powerful antioxidant action and ability to defend your skin against UV radiation are due in large part to its unique molecular design, which is responsible for lycopene's red appearance and its ability to block UV light. (2, 3) Unlike other vitamins, skin derives more of its benefits from vitamin E better through topical treatments than through oral supplements. “Tomatoes act as an astringent and can reduce the appearance of … Mozos I, Stoian D, Caraba A, Malainer C, Horbańczuk JO, Atanasov AG. 5. Lycopene's ability to enhance connectivity between cells may noticeably improve your skin's texture by aiding cellular functions that are essential to keeping your skin looking young. It should be noted that eating raw tomatoes provides only a small amount of bioavailable lycopene.4 This is because the lycopene in raw tomatoes is tightly bound to indigestible fiber that prevents much of the nutrients from being absorbed by your body.5 On the other hand, cooked tomato products such as tomato paste or tomato sauce, are a much better source of dietary lycopene.5 As far as the health of your skin is concerned, even eating cooked tomatoes may not deliver sufficient lycopene to your skin. It also boasts essential phytonutrients -- such as lycopene, beta-carotene and bioflavonoids -- that promote cellular health. Sahni S, Hannan MT, Blumberg J, Cupples LA, Kiel DP, Tucker KL. 2007;5(4):327-36. 9. The powerful antioxidant properties of lycopene fight free radicals and oxidative stress. Lycopene can benefit any skin type, but works especially well for sensitive and aging skin. Lycopene and Vascular Health. Besides protecting your skin cells from free radical damage and enhancing certain aspects of cell metabolism, lycopene also appears to produce its beneficial effects by improving the operation of cell-to-cell junctions.11 Also known as gap junctions, they coordinate cellular behavior by directly connecting the cytoplasm of two cells so that molecules and ions can pass freely between them.12,13 Gap junction communication can be found in all the different tissues of your body, with skeletal muscle and mobile cell types like sperm or red blood cells being the only exceptions.13 Gap junctions are particularly important to your skin because it is highly dependent upon intercellular communication for vital metabolic processes related to growth and reproduction. Chandra RV, Prabhuji ML, Roopa DA, Ravirajan S, Kishore HC. For the vast majority of people, the most common dietary sources of lycopene remains tomatoes, tomato-based sauces, juices, and ketchup.2. So, you will have younger-looking skin for years. Exp Biol Med (Maywood). 2009;24(6):1086-94. This fruit prevents aging, reduces wrinkles, fights blemishes, and promotes glowing skin. A recent study by Peytaev IM and colleagues1 examined the age-dependent presence of lycopene on the skin surface and the serum. Lycopene may also strengthen your skin by inhibiting the activity of enzymes involved in the destruction and breakdown of collagen. Epub 2006 Oct 17. Asia Pacific Journal of Clinical Nutrition. 2009;15(4):540-542. Nkondjock A, Ghadirian P, Johnson KC, Krewski D, Canadian Cancer Registries Epidemiology Research Group. American Journal of Clinical Nutrition. Lycopene also has compelling neurological benefits. The antioxidant (free radical scavenging) activity of lycopene exceeds that of gamma-carotene, astaxanthin, alpha-carotene, beta-carotene, zeaxanthin and lutein; it is also 100 times more powerful than alpha-tocopherol5. Lycopene content of tomatoes and tomato products. Frontiers in Pharmacology. 1999;19(2):305–323. Studies indicate that topically applied lycopene defends against skin aging by helping to stabilize DNA structure in the nucleus of skin cells, enhancing skin-cell signaling and function, and inhibiting enzymatic activity involved in collagen breakdown. Skin care companies are beginning to use topical lycopene in their formulations to offer antioxidant protection from the inside out. International Journal of Cancer. In addition, it was shown that lycopene may also protect your skin through its ability to reduce inflammation, encourage cell renewal, and inhibit normal DNA damage following UVB injury.9. Rao AV, Agarwal S. Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: A review. Food Science and Nutrition. Lycopene’s antioxidant ability to defend our skin from UV radiation can be seen as a natural form of skin protection, which is ideal for any of us looking to keep our skin youthful. 2018;9:521. 12 White, Thomas W.; Paul, David L. Genetic diseases and gene knockouts reveal diverse connexin functions. However, the fat soluble nature and relatively small molecule size of this powerful plant nutrient make it easily absorbed when applied topically in a cream or lotion. It does not cause sunburn but does age the skin; UV-B causes reddening and pain and is responsible for the majority of sunburns; A recent study by Peytaev IM and colleagues 1 examined the age-dependent presence of lycopene on the skin surface and the serum. A meta-analysis of 26 studies with 563,299 participants indicated an association of a lower risk of prostate cancer with higher lycopene supplementation and circulating concentrations7. Food and Function. Detailed information related to Lycopene Topical's uses, side-effects, reviews, questions, interactions, and precautions is as follows: Lycopene down-regulates collagenase and helps maintain natural firmness. Lycopene presence in facial skin corneocytes and sebum and its association with circulating lycopene isomer profile: Effects of age and dietary supplementation. 2002 Nov;227(10):845-51. Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk. Accessed May 25, 2012. DMAE can be consumed orally (KRS products are intended for topical, external use only, not internal), or you can apply it directly to the skin to benefit from its skin enhancing benefits. Science continues to evolve, and new research is published daily. Journal of Agroalimentary Processes and Technologies. 4. 2010 Feb;24(2):154-9. Grabowska M, Wawrzyniak D, Rolle K, Chomczynski P, Oziewicz S, JurgaS, Barciszewski J. 2005; 135(3):592-7. Lycopene is a carotenoid naturally found in tomatoes and tomato products, carrots, watermelons, papaya, apricots, pumpkin, pink grapefruits, pink guavas, rosehips and sweet potatoes6,22. © Copyright 2021 Suntory Beverage & Food Asia Pte Ltd. Petyaev IM, Pristensky DV, Morgunova EY, Zigangirova NA, Tsibezov VV, Chalyk NE, Klochkov VA, Blinova VV, Bogdanova TM, Iljin AA, Sulkovskaya LS, Chernyshova MP, Lozbiakova MV, Kyle NH, Bashmakov YK. Lycopene Crema Rinnovante The number #1 antioxidant - lycopene, along with Corylus Avellana rich in vitamin E, Calendula Officinalis contains vitamin A, Centelle Asiatica promotes collagen production, Salvia Officinalis has antibacterial and antiseptic properties, and 14 other natural botanicals. 2017;26(1):65–71, Lim S, Hwang S, Yu JH, Lim JW, Kim H. Lycopene inhibits regulator of calcineurin 1-mediated apoptosis by reducing oxidative stress and down-regulating Nucling in neuronal cells. 2019;7(4):1157-1165. Annu Rev Physiol. 12 Best Natural DHT Blockers 1. However, the lycopene level in corneocytes from the skin surface was greater in young volunteers than in middle-aged volunteers. Nutrition and Cancer. One of the biggest benefits of lycopene is that it is an antioxidant and protects the body of damage from free radical stress, which can hurt DNA and other cell structures. Chemistry and biotechnology of carotenoids. Other potential anticancer effects of lycopene are observed in lung cancer, breast cancer, colorectal cancer, gastric cancer, pancreatic cancer and ovarian cancer8-13. All Contents Copyright ©2021 Life Extension, Request FREE issue of Life Extension Magazine®, Website & Technology Accessibility Statement, An error on our end has caused the item you were trying to add to your cart to fail, please try again or call, Chemistry Panel & Complete Blood Count (CBC), http://www.smartskincare.com/treatments/topical/lycopene.html, http://www.tandfonline.com/doi/abs/10.1207/s15327914nc4702_11#preview, Topical Lycopene Improves Skin Cellular Function. 2003 Oct;83(4):1359-400. Research shows that topical application of lycopene plays an integral role in stabilizing DNA structure in the nucleus of the skin cells as well as maintaining the DNA double strand-break repair pathway. Yuan JM, Ross RK, Gao YT, Qu YH, Chu XD, Yu MC. Topical application of lycopene combats age-causing free radicals and assists in metabolic functions related to growth and repair. Tomatoes. Ascenso A, Pedrosa T, Pinho S, Pinho F, de Oliveira JM, Cabral Marques H, Oliveira H, Simões S, Santos C. The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes. bioflavanoids) that help promote skin health and general health. 2007;10(1-2):51-8. Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1. Scientifically reviewed by: Dr. Vanessa Pavey, ND, on July 2020. However, overexposure can lead to burns, blistering, sun spots and skin cancer. Lifestyle modification of the masses towards healthy foods has led to increased dietary intake of lycopene that directly coincides with the presence of lycopene in the skin. Wood LG, Garg ML, Powell H, Gibson PG. 13. Oral Health and Preventive Dentistry. Lycopene's ability to enhance connectivity and communication between cells can noticeably improve your skin's texture by aiding cellular functions that are essential to keeping your skin looking young. Unfortunately, it is mostly deposited in fat-rich organs like your adrenal glands, colon, and liver.5,6 In the end, only a small fraction of the lycopene you eat ever reaches your skin. Squalene and lycopene reduce sagginess, improve elasticity and lift and firm the skin. 14. Available at: http://www.smartskincare.com/treatments/topical/lycopene.html. Vrieling A, Voskuil DW, Bonfrer JM, Korse CM, van Doorn J, Cats A, Depla AC, Timmer R, Witteman BJ, van Leeuwen FE, Van’t Veer LJ, Rookus MA, Kampman E. Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. The ability of lycopene to block UV light is an additional benefit for the skin. 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